Facteurs de Croissance et Cytokines

Recombinant Human IFN-λ2

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Product Details

Catalogue Number: 300-02K
Description:

IFNλ1, 2, and 3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and interferons.  All three IFN-lambdas use a distinct receptor system composed of an IFN-λR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14).  Signaling through this receptor system induces antiviral defenses similar to, but distinct from, than that of type I interferons.  Recombinant Human IFN-λ2 is a 19.6 kDa protein containing 174 amino acid residues.

Source: E.coli

Synonyms: IL-28A

AA Sequence: PVARLHGALP DARGCHIAQF KSLSPQELQA FKRAKDALEE SLLLKDCRCH SRLFPRTWDL RQLQVRERPM ALEAELALTL KVLEATADTD PALVDVLDQP LHTLHHILSQ FRACIQPQPT AGPRTRGRLH HWLYRLQEAP KKESPGCLEA SVTFNLFRLL TRDLNCVASG DLCV

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells. The expected ED50 is 0.3-0.5 ng/ml.

Calculated Molecular Weight: 19.6 kDa

Accession Number: Q8IZJ0

Gene ID: 282616

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Stanifer, M L
Title
Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells.
Citation
Cell Reports; 32(1) pg107863
PubMed Id
First Author
Duong, F H
Title
IFN-λ receptor 1 expression is induced in chronic hepatitis C and correlates with the IFN-λ3 genotype and with nonresponsiveness to IFN-α therapies.
Citation
The Journal of Experimental Medicine; 211(5) pg857-68
PubMed Id
First Author
Krenn, V
Title
Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly.
Citation
Cell Stem Cell; 28(8) pg1362-1379.e7
PubMed Id