Recombinant Human IFN-γ 1 ReviewsSubmit a Review Product Details Catalogue Number: 300-02 Description: IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting cells, and antigen-recognizing B and T lymphocytes, regulates the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions, including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-γ is species-specific and is biologically active only in human and primate cells. Recombinant Human IFN-γ is a 16.8 kDa protein containing 144 amino acid residues. Source: E.coli Synonyms: Immune Interferon, type II interferon, T cell interferon, MAF AA Sequence: MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFQGR RASQ Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 determined by a cytotoxicity assay using HT-29 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 16.8 kDa Accession Number: P01579.1 Gene ID: 3458 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Fish + Virus, Human, Human + Bacteria, Human + Hamster, Human + Mouse, Human + Virus, Mandarin Fish, Monkey, Mouse, Pig, Rabbit, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 AIDS/HIV Angiogenesis/Cardiovascular Cancer Diabetes/Weight Regulation Immune System Neurobiology Stem Cells & Differentiation Allergy Transplantation product.subtitle.recentcitations First Author Amri, N Title Blood Endothelial-Cell Extracellular Vesicles as Potential Biomarkers for the Selection of Plasma in COVID-19 Convalescent Plasma Therapy. Citation Cells; 11(19) PubMed Id 36231083 First Author Duweb, A Title The SC cell line as an in vitro model of human monocytes. Citation Journal of Leukocyte Biology; 112(4) pg659-668 PubMed Id 35355303 First Author George, S Title Protocol to drive human monocyte-to-macrophage polarization in vitro using tumor conditioned media. Citation STAR Protocols; 3(4) pg101666 PubMed Id 36125932 product.subtitle.productreviews Existing reviews Confirmed dose response Used in an experiment and saw a nice dose response effect From: Lucia | Date: 24/08/2021 × Confirmed dose response Used in an experiment and saw a nice dose response effect From: Lucia | Date: 24/08/2021 Close