Facteurs de Croissance et Cytokines

Recombinant Human IFN-β

Product Details

Catalogue Number: 300-02BC
Description:

Proteins of this family play an important role in inducing non-specific resistance against a broad range of viral infections.  They also affect cell proliferation and modulate immune responses.  Produced by peripheral blood leukocytes and lymphoblastoid cells, IFN-α is an acid-stable molecule that signals through IFN-α/βR, which is also used by IFN-β.  Both IFNs have similar anti-viral activity and regulate expression of MHC class I antigens.  IFN-α contains four highly conserved cysteine residues that form two disulfide bonds, one of which is necessary for biological activity.  PeproTech’s Recombinant Human IFN-β is a 20.0 kDa protein containing 166 amino acid residues. Due to glycosylation, IFN-β has an approximate MW of 22.3 kDa based on SDS-PAGE gel and Mass Spectrometry.

*Human IFN-β (Catalog Number 300-02BC) has replaced Human IFN-β (Catalog Number 300-02B)

Source: CHO cells

Synonyms: Fibroblast Interferon, IFNB1, Type I Interferon

AA Sequence: MSYNLLGFLQ RSSNFQCQKL LWQLNGRLEY CLKDRMNFDI PEEIKQLQQF QKEDAALTIY EMLQNIFAIF RQDSSSTGWN ETIVENLLAN VYHQINHLKT VLEEKLEKED FTRGKLMSSL HLKRYYGRIL HYLKAKEYSH CAWTIVRVEI LRNFYFINRL TGYLRN

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by a cytotoxicity assay using human TF-1 cells. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.

This product has been tested against the WHO standard. International Unit information can be found here.

Calculated Molecular Weight: 20 kDa

Accession Number: P01574

Gene ID: 3456

Note:

1mg will be provided as 2x500μg.

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Liu, J S
Title
IFNs are critical regulators of IL-1 receptor antagonist and IL-1 expression in human microglia.
Citation
Journal of immunology (Baltimore, Md. : 1950); 161(4) pg1989-96
PubMed Id
First Author
Mukesh, R K
Title
Chandipura virus induces cell death in cancer cell lines of human origin and promotes tumor regression in vivo.
Citation
Molecular therapy oncolytics; 23 pg254-265
PubMed Id
First Author
Jankowski, J
Title
JAK inhibitors dampen activation of interferon-activated transcriptomes and the SARS-CoV-2 receptor ACE2 in human renal proximal tubules.
Citation
Iscience; 24(8) pg102928
PubMed Id