Recombinant Human IGF-I 1 AvisSubmit a Review Détails du Produit Catalog Number: 100-11 Description: The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant Human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds. The calculated molecular weight of Recombinant Human IGF-I is 7.6 kDa. Source: E.coli Synonyms: Insulin-like Growth Factor-I, Somatamedin C, IGF-IA AA Sequence: GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 7.6 kDa Accession Number: P05019 Gene ID: 3479 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Chicken, Cow, Dog, Frog, Hamster, Horse, Human, Monkey, Mouse, Pig, Rat, Salamander, Sheep, Zebra Fish References PubMed SDS Recherche de CoA Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Bone, Skeletal, Cartilage Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing product.subtitle.recentcitations Premier Auteur Chen, W Titre Reprogramming of human peripheral blood mononuclear cells into induced mesenchymal stromal cells using non-integrating vectors. Citation Communications Biology; 6(1) pg393 Id PubMed 37041280 Premier Auteur Pinto-Benito, D Titre IGF-1 regulates astrocytic phagocytosis and inflammation through the p110α isoform of PI3K in a sex-specific manner. Citation Glia; 70(6) pg1153-1169 Id PubMed 35175663 Premier Auteur Li, T Titre Growth factors-based platelet lysate rejuvenates skin against ageing through NF-κB signalling pathway: In vitro and in vivo mechanistic and clinical studies. Citation Cell Proliferation; 55(4) pge13212 Id PubMed 35274780 product.subtitle.productreviews Avis existants IGF-1 for Endometrial Organoid Culture Successfully cultured Endometrial Organoids using IGF-1 and HGF from Peprotech.Quick Overnight Delivery is great. De: Hardik | Date: 31/08/2020 × IGF-1 for Endometrial Organoid Culture Successfully cultured Endometrial Organoids using IGF-1 and HGF from Peprotech.Quick Overnight Delivery is great. De: Hardik | Date: 31/08/2020 Close