Facteurs de Croissance et Cytokines

Recombinant Human IL-11

Product Details

Catalogue Number: 200-11
Description:

IL-11 is a multifunctional cytokine produced by stromal cells, such as fibroblasts, epithelial cells and osteoclasts.  It is expressed in a wide variety of tissues, including thymus, lung, bone, connective tissue and central nervous system.  IL-11 plays an important regulatory role in hematopoiesis by stimulating growth of myeloid, erythroid and megakaryocyte progenitor cells.  It also regulates bone metabolism, inhibits production of proinflammatory cytokines, and protects against gastromucosal injury.  Recombinant Human IL-11 is a 19.3 kDa protein consisting of 179 amino acid residues.

Source: E.coli

Synonyms: Interleukin-11, AGIF (Adipogenesis inhibitory factor)

AA Sequence: MPGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine T11 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

Calculated Molecular Weight: 19.3 kDa

Accession Number: P20809

Gene ID: 3589

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Goff, J P
Title
Influence of cytokines on the growth kinetics and immunophenotype of daughter cells resulting from the first division of single CD34(+)Thy-1(+)lin- cells.
Citation
Blood; 92(11) pg4098-107
PubMed Id
First Author
Muszynski, K W
Title
Raf-1 protein is required for growth factor-induced proliferation of primitive hematopoietic progenitors stimulated with synergistic combinations of cytokines.
Citation
Stem cells (Dayton, Ohio); 15(1) pg63-72
PubMed Id
First Author
Goff, J P
Title
Synergistic effects of hepatocyte growth factor on human cord blood CD34+ progenitor cells are the result of c-met receptor expression.
Citation
Stem cells (Dayton, Ohio); 14(5) pg592-602
PubMed Id