Recombinant Human IL-17A 0 ReviewsSubmit a Review Product Details Catalogue Number: 200-17 Description: The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains that are secreted by activated T-cells, which act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant Human IL-17A is a 31.3 kDa, disulfide-linked homodimer of two 137 amino acid, polypeptide chains. Source: E.coli Synonyms: IL-17, CTLA-8 AA Sequence (monomer): MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Measured by its ability to induce GROα production by HT-29 cells, using a concentration range of 0.5-5.0 ng/ml. Calculated Molecular Weight: 31.3 kDa Accession Number: Q16552 Gene ID: 3605 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Cow, Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 AIDS/HIV Angiogenesis/Cardiovascular Immune System Inflammation product.subtitle.recentcitations First Author Jiménez-Andrade, Y Title The Developmental Transcription Factor p63 Is Redeployed to Drive Allergic Skin Inflammation through Phosphorylation by p38α. Citation Journal of immunology (Baltimore, Md. : 1950); 208(12) pg2613-2621 PubMed Id 35623662 First Author Hernandez, J C Title Activated and nonactivated MSCs increase survival in humanized mice after acute liver injury through alcohol binging. Citation Hepatology Communications; PubMed Id 35246968 First Author Zhang, Y Title Synthetic liver fibrotic niche extracts achieve in vitro hepatoblasts phenotype enhancement and expansion. Citation Iscience; 24(11) pg103303 PubMed Id 34765922
