Animal-Free Recombinant Human IL-17A 0 AvisSubmit a Review Détails du Produit Catalog Number: AF-200-17 Description: The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains that are secreted by activated T-cells, which act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant Human IL-17A is a 31.3 kDa, disulfide-linked homodimer of two 137 amino acid, polypeptide chains. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: IL-17, CTLA-8 AA Sequence (monomer): MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Measured by its ability to induce IL-6 production by NHDF cells using a concentration range of 0.5-1.5 ng/ml. Calculated Molecular Weight: 31.3 kDa Accession Number: Q16552 Gene ID: 3605 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) crossreactivity: Cow, Human References PubMed SDS Recherche de CoA Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 AIDS/HIV Angiogenesis/Cardiovascular Immune System Inflammation product.subtitle.recentcitations Premier Auteur Tsuji, G Titre Metformin inhibits IL-1β secretion via impairment of NLRP3 inflammasome in keratinocytes: implications for preventing the development of psoriasis Citation Cell Death Discovery; 6 pg11 Id PubMed 32194991 Premier Auteur Li, H Titre Chrysin alleviates imiquimod-induced psoriasis-like skin inflammation and reduces the release of CCL20 and antimicrobial peptides Citation Scientific Reports; 10(1) pg2932 Id PubMed 32076123 Premier Auteur Ryzhakov, G Titre IL-17 receptor adaptor protein Act1/CIKS plays an evolutionarily conserved role in antiviral signaling. Citation Journal of immunology (Baltimore, Md. : 1950); 189(10) pg4852-8 Id PubMed 23066157