Recombinant Human IL-17F 0 ReviewsSubmit a Review Product Details Catalogue Number: 200-25 Description: IL-17F, a member of the IL-17 family of structurally related cytokines, has been shown to stimulate the proliferation and activation of T cells and PBMCs. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis. The mature human IL-17F is a homodimeric protein with a total weight of 30.1 kDa, consisting of two 133 amino acid residue chains. E.coli-derived Recombinant Human IL-17F is a biologically active, non-glycosylated, disulfide-linked homodimeric protein containing 268 amino acids (30.1 kDa), including N-terminal methionine residues. Source: E.coli Synonyms: Interleukin-17F AA Sequence (monomer): MRKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHVQ Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Measured by its ability to induce IL-6 production by NHDF cells. Calculated Molecular Weight: 30.1 kDa Accession Number: Q96PD4 Gene ID: 112744 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Immune System product.subtitle.recentcitations First Author De Simone, V Title Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. Citation Oncogene; 34(27) pg3493-503 PubMed Id 25174402 First Author Boggio, E Title IL-17 protects T cells from apoptosis and contributes to development of ALPS-like phenotypes. Citation Blood; 123(8) pg1178-86 PubMed Id 24363402 First Author Edwards, L A Title Delineation of the innate and adaptive T-cell immune outcome in the human host in response to Campylobacter jejuni infection. Citation PLoS ONE; 5(11) pge15398 PubMed Id 21085698
