Animal-Free Recombinant Human IL-22 0 AvisSubmit a Review Détails du Produit Catalog Number: AF-200-22 Description: IL-22 is a member of the IL-10 family of regulatory cytokines, which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10Rβ/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant Human IL-22 is a 33.6 kDa, non-disulfide-linked, homodimeric protein consisting of two 147 amino acid polypeptide chains. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Interleukin-22, IL-TIF, Cytokine ZCYTO18 AA Sequence (monomer): MAPISSHCRL DKSNFQQPYI TNRTFMLAKE ASLADNNTDV RLIGEKLFHG VSMSERCYLM KQVLNFTLEE VLFPQSDRFQ PYMQEVVPFL ARLSNRLSTC HIEGDDLHIQ RNVQKLKDTV KKLGESGEIK AIGELDLLFM SLRNACI Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Measured by its ability to induce IL-10 secretion in COLO 205 (human colon carcinoma cells). The expected ED50 for this effect is 0.7- 1.0 ng/ml. Calculated Molecular Weight: 33.6 kDa Accession Number: Q9GZX6 Gene ID: 50616 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) crossreactivity: Human References PubMed SDS Recherche de CoA Product Line Country Of Origin: USA Not for human use. Research Interest Immune System product.subtitle.recentcitations Premier Auteur Li, H Titre Chrysin alleviates imiquimod-induced psoriasis-like skin inflammation and reduces the release of CCL20 and antimicrobial peptides Citation Scientific Reports; 10(1) pg2932 Id PubMed 32076123
