Recombinant Human IL-33 0 ReviewsSubmit a Review Product Details Catalogue Number: 200-33 Description: Human IL-33 is a proinflammatory protein that shares structural and functional characteristics with the IL-1 cytokine family. It binds and signals through the IL-1RL1/ST2 receptor, to activate NF-κB and MAP kinases. IL-33 induces production of TH2 cell related cytokines, including IL-4, IL-5 and IL-13, and exerts multiple inflammation related bioactivities. Recombinant Human IL-33 is a 17.9 kDa protein containing 159 amino acid residues. Source: E.coli Synonyms: Interleukin-33, IL-1 F11, NF-HEV AA Sequence: SITGISPITE YLASLSTYND QSITFALEDE SYEIYVEDLK KDEKKDKVLL SYYESQHPSN ESGDGVDGKM LMVTLSPTKD FWLHANNKEH SVELHKCEKP LPDQAFFVLH NMHSNCVSFE CKTDPGVFIG VKDNHLALIK VDSSENLCTE NILFKLSET Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine D10S cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107units/mg. Calculated Molecular Weight: 17.9 kDa Accession Number: O95760 Gene ID: 90865 crossreactivity: Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Immune System Inflammation product.subtitle.recentcitations First Author Qiu, J Title Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity Citation Mucosal Immunology; 14(6) pg1306-1322 PubMed Id 34349237 First Author Dustin, C M Title Oxidation-Dependent Activation of Src Kinase Mediates Epithelial IL-33 Production and Signaling during Acute Airway Allergen Challenge. Citation Journal of immunology (Baltimore, Md. : 1950); PubMed Id 34088769 First Author He, Z Title Blockade of IL-33 signalling attenuates osteoarthritis. Citation Clinical & translational immunology; 9(10) pge1185 PubMed Id 33133598
