Facteurs de Croissance et Cytokines

Recombinant Human IL-33

Product Details

Catalogue Number: 200-33
Description:

Human IL-33 is a proinflammatory protein that shares structural and functional characteristics with the IL-1 cytokine family. It binds and signals through the IL-1RL1/ST2 receptor, to activate NF-κB and MAP kinases. IL-33 induces production of TH2 cell related cytokines, including IL-4, IL-5 and IL-13, and exerts multiple inflammation related bioactivities. Recombinant Human IL-33 is a 17.9 kDa protein containing 159 amino acid residues.

Source: E.coli

Synonyms: Interleukin-33, IL-1 F11, NF-HEV

AA Sequence: SITGISPITE YLASLSTYND QSITFALEDE SYEIYVEDLK KDEKKDKVLL SYYESQHPSN ESGDGVDGKM LMVTLSPTKD FWLHANNKEH SVELHKCEKP LPDQAFFVLH NMHSNCVSFE CKTDPGVFIG VKDNHLALIK VDSSENLCTE NILFKLSET

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine D10S cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107units/mg.

Calculated Molecular Weight: 17.9 kDa

Accession Number: O95760

Gene ID: 90865

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Qiu, J
Title
Tissue signals imprint Aiolos expression in ILC2s to modulate type 2 immunity
Citation
Mucosal Immunology; 14(6) pg1306-1322
PubMed Id
First Author
Dustin, C M
Title
Oxidation-Dependent Activation of Src Kinase Mediates Epithelial IL-33 Production and Signaling during Acute Airway Allergen Challenge.
Citation
Journal of immunology (Baltimore, Md. : 1950);
PubMed Id
First Author
He, Z
Title
Blockade of IL-33 signalling attenuates osteoarthritis.
Citation
Clinical & translational immunology; 9(10) pge1185
PubMed Id