Facteurs de Croissance et Cytokines

Recombinant Human IL-34

Product Details

Catalogue Number: 200-34
Description:
Recombinant Human IL-34

IL-34 is a homodimeric cytokine that is expressed in a range of tissues that include spleen, heart, brain, liver, kidney, lung, ovary, thymus, testis, small intestine, prostate and colon. IL-34 is a ligand for colony-stimulating factor-1 receptor (CSF1R), which also binds to CSF-1. It specifically binds CD14+ monocytes, promotes survival and proliferation of human peripheral blood monocytes, and stimulates macrophage colony formation by human bone marrow cells. IL-34, like human CSF-1, stimulates phosphorylation of MAPK1/ERK2 and MAPK3/ERK1. Recombinant Human IL-34 is a 52.5 kDa homodimeric glycoprotein consisting of 460 amino acid residues, including a C-terminal His-Tag.

Source: HEK293 cells

Synonyms: Interleukin-34, C16orf77

AA Sequence (monomer): NEPLEMWPLT QNEECTVTGF LRDKLQYRSR LQYMKHYFPI NYKISVPYEG VFRIANVTRL QRAQVSEREL RYLWVLVSLS ATESVQDVLL EGHPSWKYLQ EVETLLLNVQ QGLTDVEVSP KVESVLSLLN APGPNLKLVR PKALLDNCFR VMELLYCSCC KQSSVLNWQD CEVPSPQSCS PEPSLQYAAT QLYPPPPWSP SSPPHSTGSV RPVRAQGEGL LPHHHHHHHH

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Measured by its ability to induce secretion of MCP-1 from PBMCs.

Calculated Molecular Weight: 52.5 kDa

Accession Number: Q6ZMJ4

Gene ID: 146433

Note:

1mg will be provided as 2x500μg.

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Sabate-Soler, S
Title
Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality.
Citation
Glia; 70(7) pg1267-1288
PubMed Id
First Author
Magusali, N
Title
A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene.
Citation
Brain : A Journal Of Neurology; 144(12) pg3727-3741
PubMed Id
First Author
Parajuli, B
Title
Transnasal transplantation of human induced pluripotent stem cell-derived microglia to the brain of immunocompetent mice.
Citation
Glia; 69(10) pg2332-2348
PubMed Id

product.subtitle.productreviews

Existing reviews
IL-34 for microglia differentiation
Our lab has been successfully using IL-34 to differentiate stem cells into microglia for over 1.5 year. This product goes through a rigorous quality control and always gets delivered in a timely manner.
From:  Morgane | Date:  21/07/2020