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Facteurs de Croissance et Cytokines

Recombinant Human IL-36α (IL-1F6)

Détails du Produit

Catalog Number: 200-36A
Description:

The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36α (IL-1F6), β (IL-1F8), and γ (IL-1F9). IL-36α is highly expressed in psoriatic plaques, as are IL-36β and IL-36γ, and is the only IL-1 family member found to be expressed by T cells, as well as monocytes and B cells. Primarily found in skin and lymphoid tissues, IL-36α is also found to a lesser extent in tissues of the fetal brain, trachea, stomach, and intestine. IL-36α signals through a combination of the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells, and the widely expressed IL-RAcP (IL-1 receptor accessory protein). IL-36α also functions as an agonist of NF-kappaB and MAPK pathways, and induces the production of proinflammatory cytokines and chemokines, including IL-6, IL-8, BD-2, and BD-3. Recombinant Human IL-36α is a 17.2 kDa protein containing 154 amino acid residues.

Source: E.coli

Synonyms: Interleukin-36α, IL36A, Interleukin-1 family member 6 (IL-1F6), FIL1ε (FIL1E), Interleukin-1ε (IL1E)

AA Sequence: MKIDTPQQGS IQDINHRVWV LQDQTLIAVP RKDRMSPVTI ALISCRHVET LEKDRGNPIY LGLNGLNLCL MCAKVGDQPT LQLKEKDIMD LYNQPEPVKS FLFYHSQSGR NSTFESVAFP GWFIAVSSEG GCPLILTQEL GKANTTDFGL TMLF

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Measured by its ability to induce IL-8 secretion by A431 human epidermoid carcinoma cells.

Calculated Molecular Weight: 17.2 kDa

Accession Number: Q9UBH0

Gene ID: 14440

Note:

1mg will be provided as 2x500μg.

Research Interest

Country Of Origin: USA

Not for human use.