Recombinant Human IL-8 (CXCL8) (72 a.a.) 0 ReviewsSubmit a Review Product Details Catalogue Number: 200-08M Description: IL-8 is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. IL-8 chemoattracts and activates neutrophils. Recombinant Human IL-8 (monocyte-derived) is an 8.4 kDa protein containing 72 amino acid residues. Source: E.coli Synonyms: CXCL8, monocyte-derived neutrophil chemotactic factor (MDNCF), neutrophil activating factor (NAF), NAP-1 AA Sequence: SAKELRCQCI KTYSKPFHPK FIKELRVIES GPHCANTEII VKLSDGRELC LDPKENWVQR VVEKFLKRAE NS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 10.0-100.0 ng/ml. Calculated Molecular Weight: 8.4 kDa Accession Number: P10145 Gene ID: 3576 crossreactivity: Bacteria, Human, Human + Rat, Monkey, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Apoptosis Chemotaxis Immune System Inflammation Neurobiology Wound Healing Allergy Transplantation product.subtitle.recentcitations First Author Rosenkilde, M M Title Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74. Citation The Journal of Biological Chemistry; 274(2) pg956-61 PubMed Id 9873037 First Author van den Berg, R H Title The first subcomponent of complement, C1q, triggers the production of IL-8, IL-6, and monocyte chemoattractant peptide-1 by human umbilical vein endothelial cells. Citation Journal of immunology (Baltimore, Md. : 1950); 161(12) pg6924-30 PubMed Id 9862726 First Author Petersen, F Title A chondroitin sulfate proteoglycan on human neutrophils specifically binds platelet factor 4 and is involved in cell activation. Citation Journal of immunology (Baltimore, Md. : 1950); 161(8) pg4347-55 PubMed Id 9780212
