Animal-Free Recombinant Human MCP-1 (CCL2) 0 ReviewsSubmit a Review Product Details Catalogue Number: AF-300-04 Description: The MCP proteins belong to the CC chemokine family, and signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross reacts across species. Recombinant human MCP-1 is an 8.6 kDa protein containing 76 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Monocyte Chemotactic Protein-1, CCL2, MCAF, JE (murine) AA Sequence: QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSMDHLDKQ TQTPKT Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/ml. Calculated Molecular Weight: 8.6 kDa Accession Number: P13500 Gene ID: 6347 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) crossreactivity: Bacteria, Chicken, Human, Monkey, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Cancer Chemotaxis Immune System Inflammation Neurobiology Wound Healing Allergy product.subtitle.recentcitations First Author Cross, S A Title Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: a novel candidate for HIV neuroprotection. Citation Journal of immunology (Baltimore, Md. : 1950); 187(10) pg5015-25 PubMed Id 21976775 First Author Ekert, J E Title Chemokine (C-C motif) ligand 2 mediates direct and indirect fibrotic responses in human and murine cultured fibrocytes. Citation Fibrogenesis & tissue repair; 4(1) pg23 PubMed Id 22011363 First Author Vasina, E M Title Microparticles from apoptotic platelets promote resident macrophage differentiation. Citation Cell death & disease; 2 pge211 PubMed Id 21956548
