Recombinant Human MDC (CCL22) (67 a.a.) 0 ReviewsSubmit a Review Product Details Catalogue Number: 300-36 Description: MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells, and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells, and exerts HIV-suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity, but retains HIV-suppressive activity. Recombinant Human MDC is an 8.0 kDa protein containing 67 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines. Source: E.coli Synonyms: Macrophage-Derived Chemokine, CCL22, STCP-1, ABCD-1 AA Sequence: YGANMEDSVC CRDYVRYRLP LRVVKHFYWT SDSCPRPGVV LLTFRDKEIC ADPRVPWVKM ILNKLSQ Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human T cells using a concentration range of 10.0-100.0 ng/ml. Calculated Molecular Weight: 8 kDa Accession Number: O00626 Gene ID: 6367 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Hamster, Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Chemotaxis Immune System Wound Healing product.subtitle.recentcitations First Author Anderson, C A Title A degradatory fate for CCR4 suggests a primary role in Th2 inflammation. Citation Journal of Leukocyte Biology; 107(3) pg455-466 PubMed Id 32052476 First Author Pickering, R J Title Transactivation of RAGE mediates angiotensin-induced inflammation and atherogenesis. Citation The Journal of Clinical Investigation; 129(1) pg406-421 PubMed Id 30530993 First Author Zhang, Y Title A new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma. Citation Scientific Reports; 7(1) pg15038 PubMed Id 29118379
