Facteurs de Croissance et Cytokines

MIA is the first discovered member of a family of secreted cytokines termed the MIA/OTOR family.  The four known members of this family, MIA, MIA-2, OTOR and TANGO, each contain a Src homology-3 (SH3)-like domain.  MIA is an autocrine growth regulatory protein, secreted from chondrocytes and malignant melanoma cells, that promotes melanoma metastasis by binding competitively to fibronectin and laminin in a manner that results in melanoma cell detachment from the extracellular matrix in vivo. Elevated levels of MIA may represent a clinically useful marker for diagnosis of melanoma metastasis, as well as a potential marker for rheumatoid arthritis. Recombinant Human MIA is a 12.2 kDa globular protein containing 108 amino acid residues, including two intramolecular disulfide bonds.