Neurotrophines

Recombinant Human Neurturin

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Product Details

Catalogue Number: 450-11
Description:
Recombinant Human Neurturin

Neurturin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, artemin, and persephin.  These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures.  Neurturin signals through a multicomponent receptor system, composed of RET and one of four GFRα (α1-α4) receptors.  Neurturin promotes the development and survival of sympathetic and sensory neurons by signaling through a receptor system composed of RET and GFRα2.  The functional form of human neurturin is a disulfide-linked homodimer, of two 11.8 kDa polypeptide monomers (204 total amino acid residues).  Each monomer contains seven conserved cysteine residues, one of which (Cys 69) is used for inter-chain disulfide bridging, and the others are involved in the intramolecular ring formation known as the cysteine-knot configuration.

Source: E.coli

Synonyms: NTN, NRTN

AA Sequence (monomer): ARLGARPCGL RELEVRVSEL GLGYASDETV LFRYCAGACE AAARVYDLGL RRLRQRRRLR RERVRAQPCC RPTAYEDEVS FLDAHSRYHT VHELSARECA CV

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Human Neurturin at a concentration of 100 ng/ml will support the survival of 65% of newborn rat sympathetic neurons.

Note:

1mg will be provided as 2x500μg.

Calculated Molecular Weight: 23.6 kDa

Accession Number: Q99748

Gene ID: 4902

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Schmutzler, B S
Title
Ret-dependent and Ret-independent mechanisms of Gfl-induced sensitization.
Citation
Molecular Pain; 7 pg22
PubMed Id
First Author
Vellani, V
Title
Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones.
Citation
Molecular Pain; 6 pg61
PubMed Id
First Author
Hedstrom, K L
Title
Treating small fiber neuropathy by topical application of a small molecule modulator of ligand-induced GFRα/RET receptor signaling.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 111(6) pg2325-30
PubMed Id