Neurotrophines

Recombinant Human NT-4

Product Details

Catalogue Number: 450-04
Description:

NT-4 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-3.  These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures.  NT-4 is expressed in the prostate, thymus, placenta, and skeletal muscle.  NT-4 can signal through the LNGFR and trkB receptors, and promotes the survival of peripheral sensory sympathetic neurons.  Recombinant Human NT-4 is a noncovalently linked homodimer of two 14.0 kDa polypeptide monomers (260 total amino acid residues).

Source: E.coli

Synonyms: Neurotrophin-4, Neurotrophic 4/5 (NT-4/NT-5)

AA Sequence (monomer): GVSETAPASR RGELAVCDAV SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETR CKADNAEEGG PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL TADAQGRVGW RWIRIDTACV CTLLSRTGRA

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.

Calculated Molecular Weight: 28.1 kDa

Accession Number: P34130

Gene ID: 4909

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Hanson, M G
Title
Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro.
Citation
The Journal of neuroscience : the official journal of the Society for Neuroscience; 18(18) pg7361-71
PubMed Id
First Author
Vicario-Abejón, C
Title
Neurotrophins induce formation of functional excitatory and inhibitory synapses between cultured hippocampal neurons.
Citation
The Journal of neuroscience : the official journal of the Society for Neuroscience; 18(18) pg7256-71
PubMed Id
First Author
Liou, J C
Title
Regulation of quantal secretion by neurotrophic factors at developing motoneurons in Xenopus cell cultures.
Citation
The Journal of Physiology; 503 ( Pt 1) pg129-39
PubMed Id