Recombinant Human SDF-1β (CXCL12) 0 ReviewsSubmit a Review Product Details Catalogue Number: 300-28B Description: SDF-1α and β are stromal-derived, CXC chemokines that signal through the CXCR4 receptor. SDF-1α and β chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV-suppressive activity in cells expressing the CXCR4 receptor. Human and murine SDF-1 proteins act across species. SDF-1α and β contain the four highly conserved cysteine residues present in CXC chemokines. The mature SDF-1β protein, produced by an N-terminal truncation of two additional amino acids, after removal of the signal sequence, contains 72 amino acid residues. Recombinant Human SDF-1β is an 8.5 kDa protein containing 72 amino acid residues. Source: E.coli Synonyms: Stromal-Cell Derived Factor-1, CXCL12, PBSF AA Sequence: KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNKRF KM Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract activated human T-lymphocytes using a concentration range of 10-50 ng/ml. Calculated Molecular Weight: 8.5 kDa Accession Number: P48061 Gene ID: 6387 crossreactivity: Human, Monkey References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Chemotaxis Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing product.subtitle.recentcitations First Author Campbell, J J Title Chemokines and the arrest of lymphocytes rolling under flow conditions. Citation Science (New York, N.Y.); 279(5349) pg381-4 PubMed Id 9430588 First Author Colado, A Title Immunomodulatory effects of different intravenous immunoglobulin preparations in chronic lymphocytic leukemia. Citation Scientific Reports; 11(1) pg12926 PubMed Id 34155276 First Author Gimenez, N Title Systems biology drug screening identifies statins as enhancers of current therapies in chronic lymphocytic leukemia Citation Scientific Reports; 10(1) pg22153 PubMed Id 33335123
