Recombinant Human sIL-15 Receptor α Fc 0 AvisSubmit a Review Détails du Produit Catalog Number: 200-15RA Description: IL‐15 signaling is an important factor in proliferating, activating, and immunomodulating primarily T cells. IL‐15R α is an IL‐15 specific, single pass membrane receptor which complexes with IL‐2R β and IL‐2R γ to form a high affinity IL‐15 receptor. Additionally, the IL‐15/IL‐15R complex is capable of binding to IL‐2 β/γ receptors on other cells, therefore enabling IL‐15 to indirectly activate cells expressing IL‐2 β/γ receptors. A soluble form of IL‐15 receptor α is naturally produced by proteolytic cleavage of the membrane‐bound precursor. This naturally occurring soluble form can act as a modulator of IL‐15 signaling through the inhibition of IL‐15 receptor binding. Recombinant Human sIL‐15 Receptor α Fc has a calculated molecular weight of 44.4 kDa protein and contains 408 amino acid residues, which consists of the extracellular domain of IL‐15R α fused to the Fc portion of human IgG. Due to glycosylation, it migrates at an apparent molecular weight of 50‐60 kDa, under reducing conditions. Source: Hi-5 Insect cells Synonyms: soluble Interleukin‐15 receptor subunit alpha, soluble IL‐15RA, CD215 AA Sequence: ITCPPPMSVE HADIWVKSYS LYSRERYICN SGFKRKAGTS SLTECVLNKA TNVAHWTTPS LKCIRDPALV HQRPAPPSTV TTAGVTPQPE SLSPSGKEPA ASSPSSNNTA ATTAAIVPGS QLMPSKSPST GTTEISSHES SHGTPSQTTA KNWELTASAS HQPPGVYPQG HSDTTGGPKS CDKTHTCPPC PAPELLGGPS VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVKFNWYV DGVEVHNAKT KPREEQYNST YRVVSVLTVL HQDWLNGKEY KCKVSNKALP APIEKTISKA KGQPREPQVY TLPPSRDELT KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPVLD SDGSFFLYSK LTVDKSRWQQ GNVFSCSVMH EALHNHYTQK SLSLSPGK Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit the proliferation of mouse CTLL-2 cells in the presence of Recombinant Human IL-15. Calculated Molecular Weight: 44.4 kDa Accession Number: Q13261 Gene ID: 3601 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) PubMed SDS Recherche de CoA Product Line Country Of Origin: USA Not for human use. Research Interest Immune System Neurobiology Proliferation Receptors
