Recombinant Human TGF-α

Recombinant Human TGF-α

Détails du Produit

Catalog Number: 100-16A

Description:

TGF-α is an EGF-related polypeptide growth factor that signals through the EGF receptor, and stimulates the proliferation of a wide range of epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and various tumor cells. TGF-α induces anchorage-independence transformation in cultured cells. Human, murine and rat TGF-α are cross-species reactive. Recombinant Human TGF-α is a 50 amino acid polypeptide (5.5 kDa) which shares approximately 40% sequence homology with EGF, including 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds.

Source: E.coli

Synonyms: Transforming Growth Factor-α, Sacroma growth factor, TGF-type I, ETGF

AA Sequence: VVSHFNDCPD SHTQFCFHGT CRFLVQEDKP ACVCHSGYVG ARCEHADLLA

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED₅₀ as determined by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 10⁶ units/mg.

Calculated Molecular Weight: 5.5 kDa

Accession Number: P01135

Gene ID: 7039

crossreactivity:

Chicken, Horse, Human , Mouse, Rat

Research Interest

Stem Cells & Differentiation

Angiogenesis/Cardiovascular

Country Of Origin: USA

Not for human use.

First Author

Title

Citation

Pubmed

Tong, A

Expression and effect of transforming growth factor-alpha and tumor necrosis factor-alpha in human pheochromocytoma.

Annals of the New York Academy of Sciences; 1073 pg277-83

0 Aug 2006

17102096
Show Usages

Nakanishi, Y

Loss of runt-related transcription factor 3 expression leads hepatocellular carcinoma cells to escape apoptosis.

BMC Cancer; 11 pg3

4 Jan 2011

21205319
Show Usages

Bresson, C

Large-scale analysis by SAGE reveals new mechanisms of v-erbA oncogene action.

BMC Genomics; 8 pg390

26 Oct 2007

17961265
Show Usages

Carugo, A

p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors.

Cancer Cell; 35(2) pg204-220.e9

11 Feb 2019

30753823
Show Usages

Sanghvi, V

The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase.

Cell; 178(4) pg807-819.e21

8 Aug 2019

31398338
Show Usages

Lundby, A

Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites.

Cell; 179(2) pg543-560.e26

3 Oct 2019

31585087
Show Usages

Majorini, M T

cIAP1 regulates the EGFR/Snai2 axis in triple-negative breast cancer cells.

Cell Death and Differentiation; 25(12) pg2147-2164

0 Dec 2018

29674627
Show Usages

Johnson, A L

Regulation of steroidogenic acute regulatory protein and luteinizing hormone receptor messenger ribonucleic acid in hen granulosa cells.

Endocrinology; 142(7) pg3116-24

0 Jul 2001

11416034
Show Usages

Gu, C

The role of insulin in transdifferentiated hepatocyte proliferation and function in serum-free medium.

Journal of Cellular and Molecular Medicine; 23(6) pg4165-4178

1 Jun 2019

30950200
Show Usages

Gonin-Giraud, S

Involvement of the TGF-beta and mTOR/p70S6Kinase pathways in the transformation process induced by v-ErbA.

Leukemia Research; 32(12) pg1878-88

0 Dec 2008

18573525
Show Usages

Pasupuleti, M

Antimicrobial activity of human prion protein is mediated by its N-terminal region.

PLoS ONE; 4(10) pge7358

7 Oct 2009

19809501
Show Usages

Chen, L

IÎºB kinase Î² regulates epithelium migration during corneal wound healing.

PLoS ONE; 6(1) pge16132

17 Jan 2011

21264230
Show Usages

Krall, J A

High- and low-affinity epidermal growth factor receptor-ligand interactions activate distinct signaling pathways.

PLoS ONE; 6(1) pge15945

10 Jan 2011

21264347
Show Usages

Wolf, C

ADAM17/EGFR axis promotes transglutaminase-dependent skin barrier formation through phospholipase C Î³1 and protein kinase C pathways.

Scientific Reports; 6 pg39780

22 Dec 2016

28004780
Show Usages

Tanigawa, S

Activin Is Superior to BMP7 for Efficient Maintenance of Human iPSC-Derived Nephron Progenitors.

Stem Cell Reports; 13(2) pg322-337

13 Aug 2019

31378669
Show Usages

Johansson, N

Collagenase-3 (MMP-13) is expressed by tumor cells in invasive vulvar squamous cell carcinomas.

The American Journal of Pathology; 154(2) pg469-80

0 Feb 1999

10027405
Show Usages

Haugh, J M

Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-gamma1 signaling pathway.

The Journal of Biological Chemistry; 274(13) pg8958-65

26 Mar 1999

10085141
Show Usages

Haugh, J M

Internalized epidermal growth factor receptors participate in the activation of p21(ras) in fibroblasts.

The Journal of Biological Chemistry; 274(48) pg34350-60

26 Nov 1999

10567412
Show Usages

Akiba, S

Secretory phospholipase A2 mediates cooperative prostaglandin generation by growth factor and cytokine independently of preceding cytosolic phospholipase A2 expression in rat gastric epithelial cells.

The Journal of Biological Chemistry; 276(24) pg21854-62

15 Jun 2001

11274144
Show Usages

Karki, P

cAMP response element-binding protein (CREB) and nuclear factor ÎºB mediate the tamoxifen-induced up-regulation of glutamate transporter 1 (GLT-1) in rat astrocytes.

The Journal of Biological Chemistry; 288(40) pg28975-86

4 Oct 2013

23955341
Show Usages

Zhang, X

Epidermal growth factor receptor (EGFR) signaling regulates epiphyseal cartilage development through Î²-catenin-dependent and -independent pathways.

The Journal of Biological Chemistry; 288(45) pg32229-40

8 Nov 2013

24047892
Show Usages

Tanaka, T

Ligand-activated epidermal growth factor receptor (EGFR) signaling governs endocytic trafficking of unliganded receptor monomers by non-canonical phosphorylation.

The Journal of Biological Chemistry; 293(7) pg2288-2301

16 Feb 2018

29255092
Show Usages

Chalaris, A

Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice.

The Journal of Experimental Medicine; 207(8) pg1617-24

2 Aug 2010

20603312
Show Usages

Roupé, K M

Injury is a major inducer of epidermal innate immune responses during wound healing.

The Journal of Investigative Dermatology; 130(4) pg1167-77

0 Apr 2010

19727116
Show Usages

Roupé, K M

Injury is a major inducer of epidermal innate immune responses during wound healing.

The Journal of Investigative Dermatology; 130(4) pg1167-77

0 Apr 2010

19727116
Show Usages

Plotkin, M D

Mesenchymal cells from adult kidney support angiogenesis and differentiate into multiple interstitial cell types including erythropoietin-producing fibroblasts.

American Journal of Physiology. Renal Physiology; 291(4) pgF902-12

0 Oct 2006

16622175
Show Usages

Bleeker, W K

Dual mode of action of a human anti-epidermal growth factor receptor monoclonal antibody for cancer therapy.

Journal of immunology (Baltimore, Md. : 1950); 173(7) pg4699-707

1 Oct 2004

15383606
Show Usages

Dreymueller, D

Smooth muscle cells relay acute pulmonary inflammation via distinct ADAM17/ErbB axes.

Journal of immunology (Baltimore, Md. : 1950); 192(2) pg722-31

15 Jan 2014

24342803
Show Usages

Amatngalim, G D

Basal cells contribute to innate immunity of the airway epithelium through production of the antimicrobial protein RNase 7.

Journal of immunology (Baltimore, Md. : 1950); 194(7) pg3340-50

1 Apr 2015

25712218
Show Usages

Sørensen, O E

Differential regulation of beta-defensin expression in human skin by microbial stimuli.

Journal of immunology (Baltimore, Md. : 1950); 174(8) pg4870-9

15 Apr 2005

15814714
Show Usages

Sørensen, O E

Differential regulation of beta-defensin expression in human skin by microbial stimuli.

Journal of immunology (Baltimore, Md. : 1950); 174(8) pg4870-9

15 Apr 2005

15814714
Show Usages

Hanson, M G

Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro.

The Journal of neuroscience : the official journal of the Society for Neuroscience; 18(18) pg7361-71

15 Sep 1998

9736656
Show Usages

Lindzen, M

Tailored cancer immunotherapy using combinations of chemotherapy and a mixture of antibodies against EGF-receptor ligands.

Proceedings of the National Academy of Sciences of the United States of America; 107(28) pg12559-63

13 Jul 2010

20616021
Show Usages

Jaakkola, P

Wound reepithelialization activates a growth factor-responsive enhancer in migrating keratinocytes.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology; 12(11) pg959-69

0 Aug 1998

9707168
Show Usages

Lamszus, K

Inhibition of glioblastoma angiogenesis and invasion by combined treatments directed against vascular endothelial growth factor receptor-2, epidermal growth factor receptor, and vascular endothelial-cadherin.

Clinical cancer research : an official journal of the American Association for Cancer Research; 11(13) pg4934-40

1 Jul 2005

16000592
Show Usages

Tsakiris, I

Carboxypeptidase-M is regulated by lipids and CSFs in macrophages and dendritic cells and expressed selectively in tissue granulomas and foam cells.

Laboratory investigation; a journal of technical methods and pathology; 92(3) pg345-61

0 Mar 2012

22157720
Show Usages

Watts, A E

Fetal derived embryonic-like stem cells improve healing in a large animal flexor tendonitis model.

Stem cell research & therapy; 2(1) pg4

27 Jan 2011

21272343
Show Usages