Facteurs de Croissance et Cytokines

Recombinant Human TGF-β2 (Insect derived)

Product Details

Catalogue Number: 100-35
Description:

The three mammalian isoforms of TGF-β, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix. The release of the biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. TGF-β2 has been shown to exert suppressive effects on IL-2-dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immunosurveillance of tumor development. Recombinant Human TGF-β2 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.

Source: (BTI-Tn-5B1-4) Hi-5 Insect cells

Synonyms: Transforming Growth Factor-β2, Glioblastoma-derived T cell suppressor factor, BSC-1, Cetermin, Polyergin

AA Sequence (monomer): ALDAAYCFRN VQDNCCLRPL YIDFKRDLGW KWIHEPKGYN ANFCAGACPY LWSSDTQHSR VLSLYNTINP EASASPCCVS QDLEPLTILY YIGKTPKIEQ LSNMIVKSCK CS

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The ED50 was found to be ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.

Calculated Molecular Weight: 25 kDa

Accession Number: P61812

Gene ID: 7042

Note:

250μg is the largest vial size for this product.
Larger sizes supplied as multiple 250μg vials.

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Hanson, M G
Title
Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro.
Citation
The Journal of neuroscience : the official journal of the Society for Neuroscience; 18(18) pg7361-71
PubMed Id
First Author
Xu, W W
Title
Direct Targeting of CREB1 with Imperatorin Inhibits TGFβ2-ERK Signaling to Suppress Esophageal Cancer Metastasis.
Citation
Advanced science (Weinheim, Baden-Wurttemberg, Germany); 7(16) pg2000925
PubMed Id
First Author
Beel, S
Title
κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis
Citation
Nature Communications; 11(1) pg3409
PubMed Id