Recombinant Human VEGF-C 0 ReviewsSubmit a Review Product Details Catalogue Number: 100-20CD Description: VEGF-C, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-C is expressed in various tissues, but is not produced in peripheral blood lymphocytes. It forms cell surfaced-associated, non-covalent, disulfide-linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-C may play a role in the formation of the venous and lymphatic vascular systems. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant Human VEGF-C is a disulfide-linked homodimeric protein consisting of two 13.5 kDa polypeptide chains of 116 amino acid residues. Due to glycosylation, the protein migrates as a 30.0-33.0 kDa band by SDS-PAGE analysis under non-reducing conditions. Source: HEK293 cells Synonyms: Vascular Endothelial Growth Factor-C, VRP, Flt4 ligand AA Sequence (monomer): AHYNTEILKS IDNEWRKTQC MPREVCIDVG KEFGVATNTF FKPPCVSVYR CGGCCNSEGL QCMNTSTSYL SKTLFEITVP LSQGPKPVTI SFANHTSCRC MSKLDVYRQV HSIIRR Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of human microvascular endothelial cells (HMVEC) in low serum conditions. Calculated Molecular Weight: 26.2 kDa Accession Number: P49767 Gene ID: 7424 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Cancer Immune System Inflammation Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations First Author Zhang, Y Title Lymphangiogenesis in renal fibrosis arises from macrophages via VEGF-C/VEGFR3-dependent autophagy and polarization. Citation Cell death & disease; 12(1) pg109 PubMed Id 33479195 First Author Zhang, L Title Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer. Citation Cell; 181(2) pg442-459.e29 PubMed Id 32302573 First Author Lin, T Title TGFBIp mediates lymphatic sprouting in corneal lymphangiogenesis. Citation Journal of Cellular and Molecular Medicine; 23(11) pg7602-7616 PubMed Id 31456353