Facteurs de Croissance et Cytokines

Recombinant Human VEGF121

Product Details

Catalogue Number: 100-20A
Description:
Recombinant Human VEGF 121

VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. VEGF signals through three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Due to its increased acidity, VEGF121 circulates more freely than other VEGF forms, which bind more tightly with vascular heparin sulfates. Recombinant Human VEGF121 is a 28.4 kDa, disulfide-linked homodimeric protein consisting of two 121 amino acid polypeptide chains.

Source: E.coli

Synonyms: Vascular Endothelial Growth Factor 121, VPF, VEGF-A

AA Sequence (monomer): APMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENCDKPR R

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 0.2-0.4 ng/ml.

Calculated Molecular Weight: 28.4 kDa

Accession Number: P15692

Gene ID: 7422

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

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Seki, T
Title
Interleukin-6 as an enhancer of anti-angiogenic therapy for ovarian clear cell carcinoma
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Scientific Reports; 11(1) pg7689
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Endothelial cell-derived Apelin inhibits tumor growth by altering immune cell localization
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Scientific Reports; 11(1) pg14047
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Bodda, C
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HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection.
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The Journal of Experimental Medicine; 217(7)
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product.subtitle.productreviews

Existing reviews
high quality product for vascular biology research
We use this product in our project for more than 5 years, by which the hiPSC-derived vascular endothelial cell were differentiated
From:  Ping | Date:  26/08/2020