Chémokines

Recombinant Murine CXCL16

Product Details

Catalogue Number: 250-28
Description:

CXCL16 is a member of the CXC chemokine family and signals through the CXCR6 receptor. CXCL16 may play a role in attracting lymphocyte subsets during inflammation and may facilitate certain immune responses. The chemokine domain of CXCL16 contains six cysteine residues, including the four highly conserved cysteine residues characteristic of CXC chemokines. The CXCL16 gene codes for a 273 amino acid polypeptide, which includes a 29 amino acid cytoplasmic domain and transmembrane sequence containing approximately 20 amino acids. The extracellular portion of CXCL16 contains a chemokines domain and an extended C-terminal “mucin-like stalk” sequence. The extracellular domain contains 89 amino acid residues (86 a.a. residues for the murine homolog). Recombinant Murine CXCL16 is a 9.9 kDa protein containing 88 amino acid residues.

Source: E.coli

Synonyms: SRPSOX

AA Sequence: NQGSVAGSCS CDRTISSGTQ IPQGTLDHIR KYLKAFHRCP FFIRFQLQSK SVCGGSQDQW VRELVDCFER KECGTGHGKS FHHQKHLP

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract murine lymphocytes using a concentration of 20-1000 ng/ml.

Calculated Molecular Weight: 9.9 kDa

Accession Number: Q8BSU2

Gene ID: 66102

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Di Pilato, M
Title
CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment.
Citation
Cell; 184(17) pg4512-4530.e22
PubMed Id
First Author
Lesch, S
Title
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours.
Citation
Nature Biomedical Engineering;
PubMed Id
First Author
Jacob, N
Title
Butyrate induced Tregs are capable of migration from the GALT to the pancreas to restore immunological tolerance during type-1 diabetes
Citation
Scientific Reports; 10(1) pg19120
PubMed Id