Facteurs de Croissance et Cytokines

Recombinant Murine IL-1β

Product Details

Catalogue Number: 211-11B
Description:

IL-1β is a proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes, and other epithelial cells. Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties. These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B cell maturation and proliferation, mitogenic FGF-like activity, and the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine.  Recombinant Murine IL-1β is a 17.5 kDa protein containing 153 amino acid residues.

Source: E.coli

Synonyms: Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)

AA Sequence: MVPIRQLHYR LRDEQQKSLV LSDPYELKAL HLNGQNINQQ VIFSMSFVQG EPSNDKIPVA LGLKGKNLYL SCVMKDGTPT LQLESVDPKQ YPKKKMEKRF VFNKIEVKSK VEFESAEFPN WYISTSQAEH KPVFLGNNSG QDIIDFTMES VSS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent stimulation of murine D10S cells is ≤ 0.002 ng/ml, corresponding to a specific activity of ≥ 5 x 108 units/mg.

Calculated Molecular Weight: 17.5 kDa

Accession Number: P10749

Gene ID: 16176

Note:

1mg will be provided as 2x500μg.

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Veiby, O P
Title
Inhibition of enriched stem cells in vivo and in vitro by the hemoregulatory peptide SK&F108636.
Citation
Stem cells (Dayton, Ohio); 14(2) pg215-24
PubMed Id
First Author
Ahmed, N
Title
Blood stem cell PU.1 upregulation is a consequence of differentiation without fast autoregulation.
Citation
The Journal of Experimental Medicine; 219(1)
PubMed Id
First Author
Fiancette, R
Title
Reciprocal transcription factor networks govern tissue-resident ILC3 subset function and identity
Citation
Nature Immunology; 22(10) pg1245-1255
PubMed Id