Recombinant Murine IL-22 0 ReviewsSubmit a Review Product Details Catalogue Number: 210-22 Description: IL-22 is a member of the IL-10 family of regulatory cytokines, which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10Rβ/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant Murine IL-22 is a 33.4 kDa, non-disulfide-linked, homodimeric protein consisting of two 147 amino acid polypeptide chains. Source: E.coli Synonyms: Interleukin-22, IL-TIF, Cytokine ZCYTO18 AA Sequence (monomer): MLPVNTRCKL EVSNFQQPYI VNRTFMLAKE ASLADNNTDV RLIGEKLFRG VSAKDQCYLM KQVLNFTLED VLLPQSDRFQ PYMQEVVPFL TKLSNQLSSC HISGDDQNIQ KNVRRLKETV KKLGESGEIK AIGELDLLFM SLRNACV Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to induce STAT3 activation in COLO 205 cells. The expected ED50 for this effect is 150-400 pg/ml. Calculated Molecular Weight: 33.4 kDa Accession Number: Q9JJY9 Gene ID: 50929 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Immune System product.subtitle.recentcitations First Author Melin, N Title Synergistic effect of the TLR5 agonist CBLB502 and its downstream effector IL-22 against liver injury. Citation Cell death & disease; 12(4) pg366 PubMed Id 33824326 First Author Lindborg, J A Title Optic nerve regeneration screen identifies multiple genes restricting adult neural repair. Citation Cell Reports; 34(9) pg108777 PubMed Id 33657370 First Author Shao, L Title IL-22 ameliorates LPS-induced acute liver injury by autophagy activation through ATF4-ATG7 signaling Citation Cell Death & Disease; 11(11) pg970 PubMed Id 33177520
