Facteurs de Croissance et Cytokines

Recombinant Murine IL-5

0 ReviewsSubmit a Review

Product Details

Catalogue Number: 215-15
Description:

IL-5 is a hematopoietic growth factor that stimulates the proliferation and activation of eosinophils. Produced by mast cells, T cells, and eosinophils, IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. Elevated levels of IL-5 lead to Eosinophilia, which may result in the induction of asthma and other allergic diseases. Human and murine IL-5 is cross-species reactive. Recombinant Murine IL-5 is a 26.2 kDa disulfide-linked homodimeric protein containing two 113 amino acid chains.

Source: E.coli

Synonyms: EDF, BCDFII, TRF

AA Sequence: MEIPMSTVVK ETLTQLSAHR ALLTSNETMR LPVPTHKNHQ LCIGEIFQGL DILKNQTVRG GTVEMLFQNL SLIKKYIDRQ KEKCGEERRR TRQFLDYLQE FLGVMSTEWA MEG

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

Calculated Molecular Weight: 26.2 kDa

Accession Number: P04401

Gene ID: 16191

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Wen, T
Title
Eosinophil adoptive transfer system to directly evaluate pulmonary eosinophil trafficking in vivo.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 110(15) pg6067-72
PubMed Id
First Author
de Bruin, A M
Title
Eosinophil differentiation in the bone marrow is inhibited by T cell-derived IFN-gamma.
Citation
Blood; 116(14) pg2559-69
PubMed Id
First Author
Arnold, I C
Title
The GM-CSF-IRF5 signaling axis in eosinophils promotes antitumor immunity through activation of type 1 T cell responses.
Citation
The Journal of Experimental Medicine; 217(12)
PubMed Id