Chémokines

Recombinant Murine JE/MCP-1 (CCL2)

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Product Details

Catalogue Number: 250-10
Description:

The MCP proteins are members of the CC chemokine family that signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross-reacts across species. Recombinant Murine JE is a 13.8 kDa protein containing 125 amino acid residues, including the four highly conserved cysteine residues present in the CC chemokines.

Source: E.coli

Synonyms: Monocyte Chemotactic Protein-1, CCL2, MCAF, JE (murine)

AA Sequence: QPDAVNAPLT CCYSFTSKMI PMSRLESYKR ITSSRCPKEA VVFVTKLKRE VCADPKKEWV QTYIKNLDRN QMRSEPTTLF KTASALRSSA PLNVKLTRKS EANASTTFST TTSSTSVGVT SVTVN

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract Balb/C mouse spleen MNCs using a concentration range of 1.0-20.0 ng/ml.

Calculated Molecular Weight: 13.8 kDa

Accession Number: P10148

Gene ID: 20296

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Namekata, K
Title
Roles of the DOCK-D family proteins in a mouse model of neuroinflammation.
Citation
The Journal of Biological Chemistry; 295(19) pg6710-6720
PubMed Id
First Author
Núñez, V
Title
Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 107(23) pg10626-31
PubMed Id
First Author
Tager, A M
Title
BLTR mediates leukotriene B(4)-induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis.
Citation
The Journal of Experimental Medicine; 192(3) pg439-46
PubMed Id