Facteurs de Croissance et Cytokines

Recombinant Murine Leptin

Product Details

Catalogue Number: 450-31
Description:

Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Murine Leptin is a 16.2 kDa protein containing 147 amino acid residues.

Source: E.coli

Synonyms: Obesity protein (OB)

AA Sequence: MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSAKQRVTGL DFIPGLHPIL SLSKMDQTLA VYQQVLTSLP SQNVLQIAND LENLRDLLHL LAFSKSCSLP QTSGLQKPES LDGVLEASLY STEVVALSRL QGSLQDILQQ LDVSPEC

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: PeproTech's Murine Leptin has been shown to be biologically active in two different mouse obesity models, ob/ob and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5 µg Leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed to saline-treated controls.

Calculated Molecular Weight: 16.2 kDa

Accession Number: P41160

Gene ID: 16846

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
McCowen, K C
Title
Leptin signaling in the hypothalamus of normal rats in vivo.
Citation
Endocrinology; 139(11) pg4442-7
PubMed Id
First Author
Lord, G M
Title
Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression.
Citation
Nature; 394(6696) pg897-901
PubMed Id
First Author
Igel, M
Title
Hyperleptinemia, leptin resistance, and polymorphic leptin receptor in the New Zealand obese mouse.
Citation
Endocrinology; 138(10) pg4234-9
PubMed Id