Recombinant Murine MCP-5 (CCL12) 0 ReviewsSubmit a Review Product Details Catalogue Number: 250-04 Description: The MCP proteins are members of the CC chemokine family that signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated Tcells, basophils, NK cells, and immature dendritic cells. The MCP family cross-reacts across species. Recombinant Murine MCP-5 is a 9.3 kDa protein containing 82 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines. Source: E.coli Synonyms: Monocyte Chemotactic Protein-5, CCL12 AA Sequence: GPDAVSTPVT CCYNVVKQKI HVRKLKSYRR ITSSQCPREA VIFRTILDKE ICADPKEKWV KNSINHLDKT SQTFILEPSC LG Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10.0-50.0 ng/ml. Calculated Molecular Weight: 9.3 kDa Accession Number: Q62401 Gene ID: 20293 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Cancer Chemotaxis Immune System Inflammation Neurobiology Wound Healing Allergy product.subtitle.recentcitations First Author Hansell, C A Title The Atypical Chemokine Receptor Ackr2 Constrains NK Cell Migratory Activity and Promotes Metastasis. Citation Journal of immunology (Baltimore, Md. : 1950); 201(8) pg2510-2519 PubMed Id 30158126 First Author Yagawa, Y Title Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy. Citation Scientific Reports; 7(1) pg15996 PubMed Id 29167448 First Author Singh, K Title Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities. Citation Scientific Reports; 7(1) pg4267 PubMed Id 28655871
