Chémokines

Recombinant Murine MIP-1β (CCL4)

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Product Details

Catalogue Number: 250-32
Description:
Recombinant Murine MIP-1β (CCL4)

Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (.g. macrophages, lymphocytes and NK cells). While both MIP-1α and MIP-1β exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes, and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant Murine MIP-1β is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Source: E.coli

Synonyms: Macrophage Inflammatory Protein-1β, CCL4, ACT-2

AA Sequence: APMGSDPPTS CCFSYTSRQL HRSFVMDYYE TSSLCSKPAV VFLTKRGRQI CANPSEPWVT EYMSDLELN

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human monocytes using a concentration range of 20.0-100.0 ng/ml.

Calculated Molecular Weight: 7.8 kDa

Accession Number: P14097

Gene ID: 20303

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Galeano Niño, J L
Title
Cytotoxic T cells swarm by homotypic chemokine signalling.
Citation
eLIFE; 9
PubMed Id
First Author
Martín-Leal, A
Title
CCR5 deficiency impairs CD4+ T-cell memory responses and antigenic sensitivity through increased ceramide synthesis.
Citation
The EMBO Journal; 39(15) pge104749
PubMed Id
First Author
He, H
Title
Aging-induced IL27Ra signaling impairs hematopoietic stem cells.
Citation
Blood; 136(2) pg183-198
PubMed Id