TARC, a CC chemokine, is predominantly produced by dendritic cells in the thymus, and signals through the CCR4 receptor. TARC is chemotactic towards T cells. Recombinant Murine TARC (CCL17) is an 7.9 kDa protein containing 70 amino acid residues, including the four conserved cysteine residues present in CC chemokines.
Thymus and Activation Regulated Chemokine, CCL17, ABCD-2
ARATNVGREC CLDYFKGAIP IRKLVSWYKT SVECSRDAIV FLTVQGKLIC ADPKDKHVKK AIRLVKNPRP
Calculated Molecular Weight:
≥ 98% by SDS-PAGE gel and HPLC analyses.
Determined by its ability to chemoattract murine BW5147.3 thymic lymphoma cells. The ED50 for this effect is 10-40 ng/ml.