Recombinant Rat GDNF 1 ReviewsSubmit a Review Product Details Catalogue Number: 450-51 Description: GDNF is a disulfide-linked, homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival, and morphological differentiation of midbrain neurons. Using a Parkinson’s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional rat GDNF ligand is a disulfide-linked homodimer consisting of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine-knot configuration. The calculated molecular weight of Recombinant Rat GDNF is 30.0 kDa. Source: E.coli Synonyms: Glial-Derived Neurotrophic Factor, ATF-1 AA Sequence (monomer): MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCEAAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDSLV YHILRKHSAK RCGCI Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of rat C6 cells. Calculated Molecular Weight: 30 kDa Accession Number: Q07731 Gene ID: 254535 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Organoids Angiogenesis/Cardiovascular Cell Culture Immune System Neurobiology Stem Cells & Differentiation TGF-β Superfamily product.subtitle.recentcitations First Author Nakagawa, T Title A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis. Citation Cell Reports; 37(3) pg109875 PubMed Id 34686326 First Author Zhang, X Title AKT3 Is a Pivotal Molecule of Cadherin-22 and GDNF Family Receptor-α1 Signal Pathways Regulating Self-Renewal in Female Germline Stem Cells. Citation Stem cells (Dayton, Ohio); 37(8) pg1095-1107 PubMed Id 31041846 First Author Ludtmann, M H Title α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease. Citation Nature Communications; 9(1) pg2293 PubMed Id 29895861 product.subtitle.productreviews Existing reviews Works good for cell culture We brought this product for mouse stem cell culture. From: Xiaoyu | Date: 28/07/2020 × Works good for cell culture We brought this product for mouse stem cell culture. From: Xiaoyu | Date: 28/07/2020 Close