Facteurs de Croissance et Cytokines

Recombinant Rat IFN-γ

Product Details

Catalogue Number: 400-20
Description:

IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes, as well as activated NK cells.  IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins.  This promotes the presentation of antigen to T-helper (CD4+) cells.  IFN-γ signaling in antigen-presenting cells, and antigen-recognizing B and T lymphocytes, regulates the antigen-specific phases of the immune response.  Additionally, IFN-γ stimulates a number of lymphoid cell functions, including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils.  Human IFN-γ is species-specific and is biologically active only in human and primate cells.  Recombinant Rat IFN-γ is a 15.6 kDa protein containing 135 amino acid residues.

Source: E.coli

Synonyms: Immune Interferon, type II interferon, T cell interferon, MAF

AA Sequence: MQGTLIESLE SLKNYFNSSS MDAMEGKSLL LDIWRNWQKD GNTKILESQI ISFYLRLFEV LKDNQAISNN ISVIESHLIT NFFSNSKAKK DAFMSIAKFE VNNPQIQHKA VNELIRVIHQ LSPESSLRKR KRSRC

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to inhibit the proliferation of mouse WEHI-279 cells.

Calculated Molecular Weight: 15.6 kDa

Accession Number: P01581

Gene ID: 25712

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Kanai, R
Title
Interferon-γ enhances the therapeutic effect of mesenchymal stem cells on experimental renal fibrosis
Citation
Scientific Reports; 11(1) pg850
PubMed Id
First Author
Zogbi, C
Title
Beneficial effects of IL-4 and IL-6 on rat neonatal target cardiac cells.
Citation
Scientific Reports; 10(1) pg12350
PubMed Id
First Author
Lewen, A
Title
Neuronal gamma oscillations and activity-dependent potassium transients remain regular after depletion of microglia in postnatal cortex tissue.
Citation
Journal of Neuroscience Research; 98(10) pg1953-1967
PubMed Id