Recombinant Rat IL-13 (109 a.a.) 0 ReviewsSubmit a Review Product Details Catalogue Number: 400-16 Description: IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching, resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 are cross-species reactive. Recombinant Rat IL-13 is an 11.9 kDa protein consisting of 109 amino acid residues. Source: E.coli Synonyms: NC300 (Human), P600 (Murine) AA Sequence: VRRSTSPPVA LRELIEELSN ITQDQKTSLC NSSMVWSVDL TAGGFCAALE SLTNISSCNA IHRTQRILNG LCNQKASDVA SSPPDTKIEV AQFISKLLNY SKQLFRYGH Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependant stimulation of the proliferation of human TF-1 cells is ≤ 40 ng/ml, corresponding to a specific activity of ≥ 2.5 x 104 units/mg. Calculated Molecular Weight: 11.9 kDa Accession Number: P42203 Gene ID: 116553 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 AIDS/HIV Cancer Immune System Inflammation Stem Cells & Differentiation Allergy product.subtitle.recentcitations First Author Bhushan, S Title Uropathogenic E. coli induce different immune response in testicular and peritoneal macrophages: implications for testicular immune privilege. Citation PLoS ONE; 6(12) pge28452 PubMed Id 22164293 First Author Shimizu, E Title IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia. Citation Journal of immunology (Baltimore, Md. : 1950); 181(9) pg6503-13 PubMed Id 18941241 First Author Yang, M Title Interleukin-13 enhances cyclooxygenase-2 expression in activated rat brain microglia: implications for death of activated microglia. Citation Journal of immunology (Baltimore, Md. : 1950); 177(2) pg1323-9 PubMed Id 16818793
