Recombinant Rat IL-4 0 ReviewsSubmit a Review Product Details Catalogue Number: 400-04 Description: IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant Rat IL-4 is a 14.0 kDa globular protein containing 126 amino acid residues. Source: E.coli Synonyms: BCGF, BCDF, B cell stimulating factor (BSF-1) AA Sequence: MHGCNDSPLR EIINTLNQVT EKGTPCTEMF VPDVLTATRN TTENELICRA SRVLRKFYFP RDVPPCLKNK SGVLGELRKL CRGVSGLNSL RSCTVNESTL TTLKDFLESL KSILRGKYLQ SCTSMS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate proliferation of TF-1 cells. The expected ED50 is 200-400 ng/ml. Calculated Molecular Weight: 14 kDa Accession Number: P20096 Gene ID: 287287 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, Rabbit, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Organoids COVID-19 Apoptosis Cancer Cell Culture Immune System Inflammation Stem Cells & Differentiation Allergy Transplantation product.subtitle.recentcitations First Author Prendecki, M Title Glomerulonephritis and autoimmune vasculitis are independent of P2RX7 but may depend on alternative inflammasome pathways. Citation The Journal of Pathology; 257(3) pg300-313 PubMed Id 35239186 First Author Bonito, V Title Distinct Effects of Heparin and Interleukin-4 Functionalization on Macrophage Polarization and In Situ Arterial Tissue Regeneration Using Resorbable Supramolecular Vascular Grafts in Rats. Citation Advanced Healthcare Materials; 10(21) pge2101103 PubMed Id 34523263 First Author Da-Wa, Z X Title Exosomes Derived from M2 Macrophages Exert a Therapeutic Effect via Inhibition of the PI3K/AKT/mTOR Pathway in Rats with Knee Osteoarthritic. Citation BioMed research international; 2021 pg7218067 PubMed Id 34926690
