Recombinant Rat IL-4 0 ReviewsSubmit a Review Product Details Catalogue Number: 400-04 Description: IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant Rat IL-4 is a 14.0 kDa globular protein containing 126 amino acid residues. Source: E.coli Synonyms: BCGF, BCDF, B cell stimulating factor (BSF-1) AA Sequence: MHGCNDSPLR EIINTLNQVT EKGTPCTEMF VPDVLTATRN TTENELICRA SRVLRKFYFP RDVPPCLKNK SGVLGELRKL CRGVSGLNSL RSCTVNESTL TTLKDFLESL KSILRGKYLQ SCTSMS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate proliferation of TF-1 cells. The expected ED50 is 200-400 ng/ml. Calculated Molecular Weight: 14 kDa Accession Number: P20096 Gene ID: 287287 crossreactivity: Human, Mouse, Rabbit, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Organoids COVID-19 Apoptosis Cancer Cell Culture Immune System Inflammation Stem Cells & Differentiation Allergy Transplantation product.subtitle.recentcitations First Author N'diaye, M Title C-type lectin receptors Mcl and Mincle control development of multiple sclerosis-like neuroinflammation. Citation The Journal of Clinical Investigation; 130(2) pg838-852 PubMed Id 31725411 First Author Amarnath, S Title Host-based Th2 cell therapy for prolongation of cardiac allograft viability. Citation PLoS ONE; 6(4) pge18885 PubMed Id 21559526 First Author Zogbi, C Title Beneficial effects of IL-4 and IL-6 on rat neonatal target cardiac cells. Citation Scientific Reports; 10(1) pg12350 PubMed Id 32704142
