Chémokines

Recombinant Rat RANTES (CCL5)

Product Details

Catalogue Number: 400-13
Description:

RANTES is a CC chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). Recombinant Rat RANTES is a 7.8 kDa protein containing 68 amino acid residues, including the four highly conserved cysteine residues present in the CC chemokines.

Source: E.coli

Synonyms: Regulation upon Activation Normal T cell Express Sequence, CCL5, SIS-delta

AA Sequence: SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Assay #1:  Determined by its ability to chemoattract rat peritoneal macrophages using a concentration range of 50.0-100.0 ng/ml.

Assay #2:  Determined by its ability to chemoattract human blood monocytes using a concentration range of 10.0-100.0 ng/ml.

Calculated Molecular Weight: 7.9 kDa

Accession Number: P50231

Gene ID: 81780

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
McWilliam, A S
Title
Dendritic cells are recruited into the airway epithelium during the inflammatory response to a broad spectrum of stimuli.
Citation
The Journal of Experimental Medicine; 184(6) pg2429-32
PubMed Id
First Author
Abu-Taha, M
Title
Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan.
Citation
Journal of immunology (Baltimore, Md. : 1950); 183(2) pg1393-402
PubMed Id
First Author
Abu Nabah, Y N
Title
CXCR2 blockade impairs angiotensin II-induced CC chemokine synthesis and mononuclear leukocyte infiltration.
Citation
Arteriosclerosis, Thrombosis, and Vascular Biology; 27(11) pg2370-6
PubMed Id