Recombinant Human Apo-SAA1 0 ReviewsSubmit a Review Product Details Catalogue Number: 300-53 Description: Serum amyloid A proteins (SAA) represents a family of apolipoproteins that circulates in association with high-density lipoproteins (HDL). The level of Apo-SAA, normally 1-5 μg/ml in plasma, increases 500-1000 fold within 24 hours of an inflammatory stimulus and, under these conditions, is the most abundant HDL apolipoprotein. The human SAA gene codes for a 122 amino acid nonglycosylated polypeptide, which contains an 18 amino acid N-terminal sequence. Recombinant Human Apo-SAA1 is an 11.7 kDa protein containing 105 amino acid residues. Source: E.coli Synonyms: Serum amyloid A-1 protein AA Sequence: MRSFFSFLGE AFDGARDMWR AYSDMREANY IGSDKYFHAR GNYDAAKRGP GGVWAAEAIS DARENIQRFF GHGAEDSLAD QAANEWGRSG KDPNHFRPAG LPEKY Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/ml. Calculated Molecular Weight: 11.7 kDa Accession Number: P0DJI8 Gene ID: 6288 Note: 1mg will be provided as 2x500μg. crossreactivity: Human, Mouse, Virus References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Immune System Inflammation product.subtitle.recentcitations First Author Schuchardt, M Title Dysfunctional high-density lipoprotein activates toll-like receptors via serum amyloid A in vascular smooth muscle cells. Citation Scientific Reports; 9(1) pg3421 PubMed Id 30833653 First Author Klooster, J P Title Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine Citation Communications Biology; 4(1) pg631 PubMed Id 34045640 First Author De Buck, M Title COOH-terminal SAA1 peptides fail to induce chemokines but synergize with CXCL8 and CCL3 to recruit leukocytes via FPR2. Citation Blood; 131(4) pg439-449 PubMed Id 29371208
