Animal-Free Cytokines

Animal-Free Recombinant Human BAFF

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Product Details

Catalogue Number: AF-310-13
Description:
Animal-Free Recombinant Human BAFF

BAFF, a member of the TNF family of ligands, is expressed in T cells, macrophages, monocytes and dendritic cells. BAFF is involved in stimulation of B and T cell function, and is an important survival and maturation factor for peripheral B cells. BAFF signals through three different TNF receptors, TACI, BCMA and BAFF-R. The human BAFF gene codes for a 285 amino acid type II transmembrane protein containing a 46 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 218 amino acid extracellular domain. Recombinant Human soluble BAFF is a 152 amino acid polypeptide (17.0 kDa), which contains the TNF-like portion of the extracellular domain of BAFF.

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: B cell Activating Factor belonging to the TNF family, TNFSF13B, TNFSF20, TALL-1, BLyS, THANK, ZTNF4

AA Sequence: AVQGPEETVT QDCLQLIADS ETPTIQKGSY TFVPWLLSFK RGSALEEKEN KILVKETGYF FIYGQVLYTD KTYAMGHLIQ RKKVHVFGDE LSLVTLFRCI QNMPETLPNN SCYSAGIAKL EEGDELQLAI PRENAQISLD GDVTFFGALK LL

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by a mouse splenocyte survival assay. The expected ED50 for this effect is 0.5-2.0 µg/ml.

Calculated Molecular Weight: 17 kDa

Accession Number: Q9Y275

Gene ID: 10673

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Benson, M J
Title
Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) and elongation factor, RNA polymerase II, 2 (ELL2) are regulators of mRNA processing in plasma cells.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 109(40) pg16252-7
PubMed Id
First Author
Saada, S
Title
Differential expression of neurotensin and specific receptors, NTSR1 and NTSR2, in normal and malignant human B lymphocytes.
Citation
Journal of immunology (Baltimore, Md. : 1950); 189(11) pg5293-303
PubMed Id
First Author
Mahévas, M
Title
B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells.
Citation
The Journal of Clinical Investigation; 123(1) pg432-42
PubMed Id