Other Proteins

Recombinant Human BD-1 (36 a.a.)

Product Details

Catalogue Number: 300-51
Description:

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system.  The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6.  β-defensins are expressed on some leukocytes and at epithelial surfaces.  In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells.  The β-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence.  β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds.  Recombinant Human BD-1 is a 3.9 kDa protein containing 36 amino acid residues.

Source: E.coli

Synonyms: Beta-Defensin 1, DEFB1, HBD1

AA Sequence: DHYNCVSSGG QCLYSACPIF TKIQGTCYRG KAKCCK

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 100.0-1000.0 ng/ml.

Calculated Molecular Weight: 3.9 kDa

Accession Number: P60022

Gene ID: 1672

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Dietrich, D E
Title
Human β-defensin HBD3 binds to immobilized Bla g2 from the German cockroach (Blattella germanica).
Citation
Peptides; 53 pg265-9
PubMed Id
First Author
Borgwardt, D S
Title
Histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and alters HagB-induced chemokine responses.
Citation
Scientific Reports; 4 pg3904
PubMed Id
First Author
Bryan, J D
Title
Streptococcus agalactiae CspA is a serine protease that inactivates chemokines.
Citation
Journal of Bacteriology; 191(6) pg1847-54
PubMed Id