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Other Proteins

Recombinant Human BD-1 (47 a.a.)

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Product Details

Catalogue Number: 300-51A
Recombinant Human BD-1 (47 a.a.)

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system.  The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds.  To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6.  β-defensins are expressed on some leukocytes and at epithelial surfaces.  In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells.  The β-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence.  β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds.  Recombinant Human BD-1 is a 5.0 kDa protein containing 47 amino acid residues.

Source: E.coli

Synonyms: Beta-Defensin 1, DEFB1, HBD1


Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 100.0-1000.0 ng/ml.

Calculated Molecular Weight: 5 kDa

Accession Number: P60022

Gene ID: 1672

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

Country Of Origin: USA

Not for human use.

Research Interest


First Author
Wilson, C L
Differential Processing of {alpha}- and {beta}-Defensin Precursors by Matrix Metalloproteinase-7 (MMP-7).
The Journal of Biological Chemistry; 284(13) pg8301-11
PubMed Id
First Author
Schibli, D J
The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus.
The Journal of Biological Chemistry; 277(10) pg8279-89
PubMed Id