Recombinant Human BMP-13/CDMP-2 0 ReviewsSubmit a Review Product Details Catalogue Number: 120-04 Description: BMP-13 is expressed in hypertrophic chondrocytes during embryonic development of long bones. Continued postnatal expression of BMP-13 in articular cartilage suggests that it plays a regulatory role in the growth and maintenance of articular cartilage. Adenovirus-mediated BMP-13 gene transfer to rabbit bone marrow stem cells have been reported to augment periosteal repair of osteochondral defects. The functional form of BMP-13/CDMP-2 is a disulfide-linked homodimer of two 120 amino acid polypeptide chains. This 27.5 kDa protein is obtained by proteolytic processing of a biologically inactive precursor protein of 97.7 kDa. Recombinant Human BMP-13/CDMP-2 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains. Source: E.coli Synonyms: Bone Morphogenetic Protein-13, GDF-6, Cartilage-Derived Morphogenetic Protein-2 (CDMP-2) AA Sequence (monomer): TAFASRHGKR HGKKSRLRCS KKPLHVNFKE LGWDDWIIAP LEYEAYHCEG VCDFPLRSHL EPTNHAIIQT LMNSMDPGST PPSCCVPTKL TPISILYIDA GNNVVYKQYE DMVVESCGCR Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells in the range of 2.0-3.0 µg/ml. Calculated Molecular Weight: 27 kDa Accession Number: Q6KF10 Gene ID: 392255 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Bone, Skeletal, Cartilage Cell Culture Immune System Stem Cells & Differentiation TGF-β Superfamily product.subtitle.recentcitations First Author Shen, B Title BMP-13 emerges as a potential inhibitor of bone formation. Citation International Journal of Biological Sciences; 5(2) pg192-200 PubMed Id 19240811
