Animal-Free Recombinant Human BMP-4 (E.coli derived) 1 ReviewsSubmit a Review Product Details Catalogue Number: AF-120-05ET Description: Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body, and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. PeproTech’s E.coli-derived BMP-4 is a fully active homodimeric protein consisting of two 106 amino acid subunits, which correspond to amino acids 303-408 of the full length BMP-4 precursor. The calculated molecular weight of Recombinant Human BMP-4 (E.coli-derived) is 23.9 kDa. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Bone Morphogenetic Protein-4, BMP-2B, DVR4 AA Sequence (monomer): KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-10 ng/ml. Calculated Molecular Weight: 23.9 kDa Accession Number: P12644 Gene ID: 652 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) Note: 1mg will be provided as 2x500μg. crossreactivity: Human, Mouse, Rat, Salamander References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Organoids Angiogenesis/Cardiovascular Apoptosis Bone, Skeletal, Cartilage Cell Culture Immune System Neurobiology Stem Cells & Differentiation TGF-β Superfamily product.subtitle.recentcitations First Author Duan, X Title An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection. Citation Cell Reports; 37(6) pg109920 PubMed Id 34731648 First Author Marinopoulou, E Title HES1 protein oscillations are necessary for neural stem cells to exit from quiescence. Citation Iscience; 24(10) pg103198 PubMed Id 34703994 First Author Marqués-Torrejón, M Á Title LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells Citation Nature Communications; 12(1) pg2594 PubMed Id 33972529 product.subtitle.productreviews Existing reviews BMP4 reliable product for my differentiation protocols that was easy to reconstitute and adjust dosage! From: Eman | Date: 15/07/2020 × BMP4 reliable product for my differentiation protocols that was easy to reconstitute and adjust dosage! From: Eman | Date: 15/07/2020 Close
