Recombinant Human BMP-5 0 ReviewsSubmit a Review Product Details Catalog Number: 120-39 Description: TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth, and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling, and maintenance of a variety of other tissues and organs. BMP-5 is expressed in the nervous system, lungs and liver. It is a known regulator for dendritic growth in sympathetic neurons. BMP-5 is a 454 amino acid precursor protein that is cleaved to release the biologically active C-terminal mature protein. Recombinant Human BMP-5 is a 31.2 kDa homodimeric disulfide-linked protein consisting of two identical 138 amino acid chains. Source: CHO cells Synonyms: Bone Morphogenetic Protein-5 AA Sequence (monomer): AANKRKNQNR NKSSSHQDSS RMSSVGDYNT SEQKQACKKH ELYVSFRDLG WQDWIIAPEG YAAFYCDGEC SFPLNAHMNA TNHAIVQTLV HLMFPDHVPK PCCAPTKLNA ISVLYFDDSS NVILKKYRNM VVRSCGCH Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.0 µg/ml. Calculated Molecular Weight: 31.2 kDa Accession Number: P22003 Gene ID: 653 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 250μg is the largest vial size for this product. Larger sizes supplied as multiple 250μg vials. Cross Reactivity Cited in References: Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Bone, Skeletal, Cartilage Cell Culture Immune System Neurobiology Stem Cells & Differentiation TGF-β Superfamily Recent Citations First Author Guo, D Title Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapse. Citation The Journal of Experimental Medicine; 218(9) PubMed ID 34254999 First Author Junk, D J Title Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling. Citation Oncogene; 36(28) pg4001-4013 PubMed ID 28288136
