Recombinant Human EPO 0 ReviewsSubmit a Review Product Details Catalogue Number: 100-64 Description: Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. The differentiation of CFU-E (Colony Forming Unit-Erythroid) cells into erythrocytes can only be accomplished in the presence of EPO. Physiological levels of EPO in adult mammals are maintained primarily by the kidneys, whereas levels in fetal or neonatal mammals are maintained by the liver. EPO also can exert various non-hematopoietic activities, including vascularization and proliferation of smooth muscle, neural protection during hypoxia, and stimulation of certain B cells. PeproTech’s Human EPO contains 166 amino acid residues and has a calculated molecular weight of approximately 18.4 kDa. As a result of glycosylation, Recombinant Human EPO migrates with an apparent molecular mass of 37.0 kDa by SDS-PAGE gel, under reducing and non-reducing conditions. Source: CHO cells Synonyms: Erythropoietin, Epoetin AA Sequence: APPRLICDSR VLERYLLEAK EAENITTGCA EHCSLNENIT VPDTKVNFYA WKRMEVGQQA VEVWQGLALL SEAVLRGQAL LVNSSQPWEP LQLHVDKAVS GLRSLTTLLR ALGAQKEAIS PPDAASAAPL RTITADTFRK LFRVYSNFLR GKLKLYTGEA CRTGDR Purity: ≥ 90% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by a cell proliferation assay using TF-1 cells. The expected ED50 for this effect is 0.8-1.0 ng/ml. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 18.4 kDa Accession Number: P01588 Gene ID: 2056 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Human + Virus, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Immune System Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations First Author Chen, W Title Reprogramming of human peripheral blood mononuclear cells into induced mesenchymal stromal cells using non-integrating vectors. Citation Communications Biology; 6(1) pg393 PubMed Id 37041280 First Author Atkins, M H Title Modeling human yolk sac hematopoiesis with pluripotent stem cells. Citation The Journal of Experimental Medicine; 219(3) PubMed Id 34928315 First Author Ito, K Title Single-chain tandem macrocyclic peptides as a scaffold for growth factor and cytokine mimetics. Citation Communications Biology; 5(1) pg56 PubMed Id 35031676
