Recombinant Human FGF-18 0 ReviewsSubmit a Review Product Details Catalogue Number: 100-28 Description: FGF-18 is a heparin-binding growth factor that belongs to the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-18 is an essential regulator of long bone and calvarial development. FGF-18 signals through FGFR 1c, 2c, 3c, and 4. Recombinant Human FGF-18 derived from E.coli is a 20.1 kDa protein consisting of 173 amino acid residues, resulting from C-terminal truncation of the full length protein. Source: E.coli Synonyms: Fibroblast Growth Factor-18, zFGF5, FGFI AA Sequence: AEENVDFRIH VENQTRARDD VSRKQLRLYQ LYSRTSGKHI QVLGRRISAR GEDGDKYAQL LVETDTFGSQ VRIKGKETEF YLCMNRKGKL VGKPDGTSKE CVFIEKVLEN NYTALMSAKY SGWYVGFTKK GRPRKGPKTR ENQQDVHFMK RYPKGQPELQ KPFKYTTVTK RSR Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 10 ng/ml, corresponding to a specific activity of ≥ 1 x 105 units/mg. Calculated Molecular Weight: 20.1 kDa Accession Number: O76093 Gene ID: 8817 crossreactivity: Human, Mouse, Rat, Sheep References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Bone, Skeletal, Cartilage Cancer FGF Superfamily Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing product.subtitle.recentcitations First Author Merrill, A E Title Bent bone dysplasia-FGFR2 type, a distinct skeletal disorder, has deficient canonical FGF signaling. Citation American Journal of Human Genetics; 90(3) pg550-7 PubMed Id 22387015 First Author Zhang, X Title Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. Citation The Journal of Biological Chemistry; 281(23) pg15694-700 PubMed Id 16597617 First Author Smith, L B Title Fibroblast growth factor receptor 3 effects on proliferation and telomerase activity in sheep growth plate chondrocytes. Citation Journal of Animal Science and Biotechnology; 3(1) pg39 PubMed Id 23216972
