Recombinant Human FGF-21 0 ReviewsSubmit a Review Product Details Catalogue Number: 100-42 Description: FGF-21 is a secreted growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-21, in the presence of β-Klotho as a protein cofactor, signals through the FGFR 1c and 4 receptors, and stimulates insulin-independent glucose uptake by adipocytes. Recombinant Human FGF-21 is a 19.5 kDa protein containing 182 amino acid residues. Source: E.coli Synonyms: Fibroblast Growth Factor-21, FGFL AA Sequence: MHPIPDSSPL LQFGGQVRQR YLYTDDAQQT EAHLEIREDG TVGGAADQSP ESLLQLKALK PGVIQILGVK TSRFLCQRPD GALYGSLHFD PEACSFRELL LEDGYNVYQS EAHGLPLHLP GNKSPHRDPA PRGPARFLPL PGLPPALPEP PGILAPQPPD VGSSDPLSMV GPSQGRSPSY AS Purity: ≥ 90% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of murine NIH-3T3 cells. Calculated Molecular Weight: 19.5 kDa Accession Number: Q9NSA1 Gene ID: 26291 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Bone, Skeletal, Cartilage Cancer FGF Superfamily Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing product.subtitle.recentcitations First Author Wu, T Title Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway. Citation The Journal of Experimental Medicine; 218(6) PubMed Id 33856409 First Author Kim, H Y Title Hepatic STAMP2 mediates recombinant FGF21-induced improvement of hepatic iron overload in nonalcoholic fatty liver disease. Citation FASEB journal : official publication of the Federation of American Societies for Experimental Biology; 34(9) pg12354-12366 PubMed Id 32721044 First Author Cinque, L Title MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B. Citation The EMBO Journal; pge105696 PubMed Id 32716134
