Growth Factors & Cytokines

Recombinant Human FGF-21

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Product Details

Catalogue Number: 100-42
Description:

FGF-21 is a secreted growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-21, in the presence of β-Klotho as a protein cofactor, signals through the FGFR 1c and 4 receptors, and stimulates insulin-independent glucose uptake by adipocytes. Recombinant Human FGF-21 is a 19.5 kDa protein containing 182 amino acid residues.

Source: E.coli

Synonyms: Fibroblast Growth Factor-21, FGFL

AA Sequence: MHPIPDSSPL LQFGGQVRQR YLYTDDAQQT EAHLEIREDG TVGGAADQSP ESLLQLKALK PGVIQILGVK TSRFLCQRPD GALYGSLHFD PEACSFRELL LEDGYNVYQS EAHGLPLHLP GNKSPHRDPA PRGPARFLPL PGLPPALPEP PGILAPQPPD VGSSDPLSMV GPSQGRSPSY AS

Purity: ≥ 90% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate the proliferation of murine NIH-3T3 cells.

Calculated Molecular Weight: 19.5 kDa

Accession Number: Q9NSA1

Gene ID: 26291

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Wu, T
Title
Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway.
Citation
The Journal of Experimental Medicine; 218(6)
PubMed Id
First Author
Cinque, L
Title
MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B.
Citation
The EMBO Journal; pge105696
PubMed Id
First Author
Jiang, S
Title
Fibroblast growth factor 21 is regulated by the IRE1α-XBP1 branch of the unfolded protein response and counteracts endoplasmic reticulum stress-induced hepatic steatosis.
Citation
The Journal of Biological Chemistry; 289(43) pg29751-65
PubMed Id