Recombinant Human G-CSF 0 ReviewsSubmit a Review Product Details Catalogue Number: 300-23 Description: G-CSF is a hematopoietic growth factor that stimulates the development of committed progenitor cells to neutrophils and enhances the functional activities of the mature end-cell. It is produced in response to specific stimulation by a variety of cells, including macrophages, fibroblasts, endothelial cells and bone marrow stroma. G-CSF is being used clinically to facilitate hematopoietic recovery after bone marrow transplantation. Human and murine G-CSF are cross-species reactive. Recombinant Human G-CSF is an 18.7 kDa protein consisting of 174 amino acid residues. Source: E.coli Synonyms: Granulocyte Colony-Stimulating Factor, CSF-3, MGI-1G, GM-CSF beta, pluripoietin AA Sequence: TPLGPASSLP QSFLLKCLEQ VRKIQGDGAA LQEKLCATYK LCHPEELVLL GHSLGIPW APLSSCPSQA LQLAGCLSQL HSGLFLYQGL LQALEGISPE LG PTLDTL QLDVADFATT IWQQMEELGM APALQPTQGA MPAFASAFQR RAGG VLVA SHLQSFLEVS YRVLRHLAQP Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of murine NFS-60 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 18.7 kDa Accession Number: P09919 Gene ID: 1440 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Human + Mouse, Human + Virus, Monkey, Mouse, Pig, Plant References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Angiogenesis/Cardiovascular Cancer Diabetes/Weight Regulation Immune System Inflammation Stem Cells & Differentiation product.subtitle.recentcitations First Author Loef, E J Title Plasminogen and plasmin can bind to human T cells and generate truncated CCL21 that increases dendritic cell chemotactic responses. Citation The Journal of Biological Chemistry; 298(7) pg102112 PubMed Id 35690148 First Author Díaz de la Guardia, R Title Engraftment characterization of risk-stratified AML in NSGS mice. Citation Blood Advances; 5(23) pg4842-4854 PubMed Id 34470043 First Author Bent, E H Title Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy. Citation Nature Communications; 12(1) pg6218 PubMed Id 34711820
