Animal-Free Recombinant Human G-CSF 0 ReviewsSubmit a Review Product Details Catalog Number: AF-300-23 Description: G-CSF is a hematopoietic growth factor that stimulates the development of committed progenitor cells to neutrophils and enhances the functional activities of the mature end-cell. It is produced in response to specific stimulation by a variety of cells, including macrophages, fibroblasts, endothelial cells and bone marrow stroma. G-CSF is being used clinically to facilitate hematopoietic recovery after bone marrow transplantation. Human and murine G-CSF are cross-species reactive. Recombinant Human G-CSF is an 18.7 kDa protein consisting of 174 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Granulocyte Colony-Stimulating Factor, CSF-3, MGI-1G, GM-CSFβ, pluripoietin AA Sequence: TPLGPASSLP QSFLLKCLEQ VRKIQGDGAA LQEKLCATYK LCHPEELVLL GHSLGIPWAP LSSCPSQALQ LAGCLSQLHS GLFLYQGLLQ ALEGISPELG PTLDTLQLDV ADFATTIWQQ MEELGMAPAL QPTQGAMPAF ASAFQRRAGG VLVASHLQSF LEVSYRVLRH LAQP Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of mouse NFS-60 cells. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 18.7 kDa Accession Number: P09919 Gene ID: 1440 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) Cross Reactivity Cited in References: Human, Mouse, Plant References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Angiogenesis/Cardiovascular Cancer Diabetes/Weight Regulation Immune System Inflammation Stem Cells & Differentiation Recent Citations First Author Murthy, S Title Danger signal extracellular calcium initiates differentiation of monocytes into SPP1/osteopontin-producing macrophages. Citation Cell death & disease; 13(1) pg53 PubMed ID 35022393 First Author Thomé, C H Title NTAL is associated with treatment outcome, cell proliferation and differentiation in acute promyelocytic leukemia Citation Scientific Reports; 10(1) pg10315 PubMed ID 32587277 First Author Xu, Y Title TAF1 plays a critical role in AML1-ETO driven leukemogenesis. Citation Nature Communications; 10(1) pg4925 PubMed ID 31664040